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深度整合研发经验,不断攀登研发技术高峰,搭建新药研发一体化创新服务平台。
Cancer Type | Cell Lines |
---|---|
Breast Cancer | 4T1,EMT6,JC,C1271 |
Lung Cancer | LLC1(LLC1-luc),KLN205 |
Colon Cancer | CT26.WT, MC-38, CMT-93 |
Pancreas Cancer | Panc 02 |
Renal Cancer | RENCA |
Melanoma | B16-F10(B16-F10-luc),Clone-M3 |
Liver Cancer | H22,Hepa 1-6 |
Lymphoma | A20,EL4,P388D1,L5178-R,E.G7-OVA |
Leukemia | C1498,L1210,WEHI-3 |
Myeloma | J558 |
Mastocytoma | P815 |
Cancer Type | Cell Lines | Cancer Type | Cell Lines |
---|---|---|---|
Breast Cancer | HCC1954 | Lymphoma | Raji, MOLM-13 |
Colon Cancer | HT29, Lovo, Ls174T | Myeloma | NCI-H929 |
Lung Cancer | NCI-H292, HCC827 | Skin Cancer | A431 |
Leukemia (AML) | THP-1 | Ovarian Cancer | OVCAR-3 |
Cancer Type | Cell Lines |
---|---|
Brain Cancer | U-87 MG |
Breast Cancer | HCC1954, MDA-MB-231, JIMT-1 |
Colon Cancer | HT29, LoVo |
Gastric Cancer | NCI-N87 |
Lung Cancer | HCC827, NCI-H1975, NCI-H292, A549 |
Lymphoma | Raji, TMD8, MOLM-13 |
Myeloma | RPMI-8226, NCI-H929 |
Pancreatic Cancer | Capan-2 |
Skin Cancer | A431 |
Urinary Bladder Cancer | UM-UC-3 |
Cancer Type | Orthotopic Model | Orthotopic Model (Luc Cell Line) |
---|---|---|
Brain Cancer | U87-MG | U87-MG-luc |
Lung cancer | NCI-H1650, A549, NCI-H1975, NCI-H460, LLC1 | A549-luc,LLC1-luc, NCI-H1975-luc |
Colon cancer | HCT-116, LoVo | HT29-luc |
Gastric cancer | Hs 746T | |
Pancreas cancer | Mia-Paca 2 | Mia-Paca ;2-luc |
Breast cancer | MDA-MB-231 | 4T1-luc |
Ovarian cancer | SK-OV-3 | SK-OV-3-luc |
Prostate Cancer | PC3 | PC-3-luc |
Renal Cancer | A498 | |
Bladder Cancer | UM-UC-3 | |
Melanoma | B16-F10-luc | |
Liver Cancer | H22 | |
Bone Cancer |
脑部原位移植
肺转移模型
胫骨骨髓腔原位移植
卵巢癌原位移植
Cancer Type | Cell Lines |
---|---|
Colon Cancer | PDXM-008C, PDXM-016C, PDXM-020C, PDXM-021C, PDXM-057C, PDXM-060C, PDXM-075C, PDXM-076C, PDXM-087C, PDXM-104C, PDXM-095C, PDXM-084C, PDXM-072C, PDXM-069C, PDXM-057C, PDXM-015C, PDXM-002C, |
Lung Cancer | PDXM-054Lu, PDXM-050Lu, PDXM-047Lu, PDXM-053Lu, PDXM-028Lu, |
Gastric Cancer | PDXM-092Ga, PDXM-091Ga, |
Breast Cancer | PDXM-201B, PDXM-202B, PDX-203B |
Liver Cancer | PDXM-211Li, PDXM-212Li |
Pancreas Cancer | PDXM-221Pa, PDXM-222Pa |
Bladder Cancer | PDXM-231U, PDXM-232U |
Lymphoma | PDXM-241Ly, PDXM-242Ly |
1.被动免疫【作用于肿瘤】
• 抗肿瘤单抗(EGFR、 Her2单抗)
• 过继性免疫治疗(过继细胞转移, CAR-T)
2.主动免疫【作用于免疫系统】
• 增强机体的免疫功能(细胞因子)
• 抗原依赖(治疗性疫苗)
• 非抗原依赖(调节免疫细胞功能,I/0抑制剂)
嵌合抗原受体T细胞(CAR-T,Chimeric antigen receptor T cell)是指通过基因修饰技术,将带有特异性抗原识别结构域及T细胞激活信号的遗传物质转入T细胞,使T细胞通过直接与肿瘤细胞表面的特异性抗原相结合而激活,通过释放穿孔素、颗粒酶素B等直接杀伤肿瘤细胞,同时还通过释放细胞因子募集人体内源性免疫细胞杀伤肿瘤细胞,从而达到治疗肿瘤的目的,而且还可形成免疫记忆T细胞从而获得特异性的抗肝瘤长效机制。
a)同源小鼠模型(Syngeneic Mouse)完整的免疫系统
b)转基因小鼠(Transgenic Mouse),免疫系统正常
c)移植瘤鼠模型(Human Xenograft Mouse)
d)免疫系统重建人源化小鼠模型(HIS小鼠, Humanized Immune System mice, HIS mice)